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Serial analysis of gene expression: ESTs get smaller
Author(s) -
Adams Mark D.
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180402
Subject(s) - gene , expressed sequence tag , biology , gene expression , computational biology , sequence (biology) , genetics , serial analysis of gene expression , sequence analysis , regulation of gene expression , gene expression profiling
Abstract Measuring gene expression on a global scale has been one of the vexing problems of cell biology. Velculescu et al . (1) recently proposed a system for identifying gene expression levels based on very short sequence tags – about nine base pairs – located at a specific site within a gene transcript. By coupling the strategy to current automated sequencing machines and the large expressed sequence tag databases, it should be possible to follow changes in gene expression for large numbers of genes economically and accurately.