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Src and the control of cell division
Author(s) -
Taylor Stephen J.,
Shalloway David
Publication year - 1996
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950180105
Subject(s) - cell cycle , cell division , biology , proto oncogene tyrosine protein kinase src , microbiology and biotechnology , cell , cell growth , oncogene , dna synthesis , genetics , dna , cancer research , signal transduction
The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto‐oncogene products as important players in cell‐cycle regulation. One such proto‐oncoprotein, c‐Src, has previously been directly implicated, based on its requirement for growth factor‐stimulated DNA synthesis. Roche et al . (1) have now shown that c‐Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto‐oncoproteins.