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Chromosomes take an active role in spindle assembly
Author(s) -
Waters Jennifer C.,
Salmon Edward D.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950171102
Subject(s) - kinetochore , centrosome , chromosome segregation , spindle pole body , spindle apparatus , microbiology and biotechnology , biology , spindle checkpoint , cell division , chromosome , genetics , cell , cell cycle , gene
The assembly of a bipolar spindle is essential for the accurate segregation of replicated chromosomes during cell division. Do chromosomes rely solely on other cellular components to regulate the assembly of the bipolar spindle or are they masters of their own fate? In the Zhang and Nicklas (1) study reviewed here, micromanipulation techniques and video microscopy were used to demonstrate the different roles that chromosome arms, kinetochores and centrosomes play in bipolar spindle assembly.