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DNA topoisomerase II mutations and resistance to anti‐tumor drugs
Author(s) -
Vassetzky Yegor S.,
Alghisi GianCarlo,
Gasser Susan M.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170906
Subject(s) - topoisomerase , biology , drug resistance , dna , mutation , drug , topoisomerase inhibitor , cancer research , gene , genetics , pharmacology
Mutations in DNA topoisomerase II are often correlated with drug‐resistance in tumor cell lines. Studies of topoisomerase II‐mediated drug‐resistance in various model systems, as well as the sequencing of such mutations from drug‐resistant tumors, have shed light on the functional domains of topoisomerase II, on how it interacts with inhibitors, and on the different mechanisms by which cells avoid the toxic effects of many clinically important anti‐tumor drugs.