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Drosophila WARTS–tumor suppressor and member of the myotonic dystrophy protein kinase family
Author(s) -
Watson Kellie L.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170803
Subject(s) - biology , suppressor , gene , myotonic dystrophy , tumor suppressor gene , genetics , cell growth , cyclin dependent kinase 8 , microbiology and biotechnology , cancer research , carcinogenesis , notch signaling pathway
Tumor suppressor genes represent a broad class of genes that normally function in the negative regulation of cell proliferation. Loss‐of‐function mutations in these genes lead to unrestrained cell proliferation and tumor formation. A fundamental understanding of how tumor suppressor genes regulate cell proliferation and differentiation should reveal important aspects of signalling pathways and cell cycle control. A recent report describing the Drosophila tumor suppressor gene warts has implications in the study of the human myotonic dystrophy gene (1) . These genes encode members of a cyclic AMP‐dependent protein kinase subfamily that includes other plant and animal orthologues.