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Stopped for repairs
Author(s) -
Sanchez Yolanda,
Elledge Stephen J.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170611
Subject(s) - gadd45 , dna damage , dna repair , proliferating cell nuclear antigen , biology , dna , microbiology and biotechnology , dna replication , gene , cell cycle , nucleotide excision repair , cell cycle checkpoint , genetics
The tumor suppressor protein p53 is intimately involved in the cellular response to DNA damage, controlling cell cycle arrest, apoptosis and the transcriptional induction of DNA damage inducible genes. A transcriptional target of p53, Gadd45, was recently found to bind to PCNA, a component of DNA replication/repair complexes, thereby implicating Gadd45 in DNA metabolism (1) . Using biochemical assays, a role for Gadd45 in excision repair in vitro has been demonstrated (1) . Antisense experiments have also indicated an in vivo role for the GADD45 gene in UV‐irradiation survival. These discoveries establish a link between p53 and DNA repair through Gadd45.