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Compartments and appendage development in Drosophila
Author(s) -
Blair Seth S.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170406
Subject(s) - compartmentalization (fire protection) , compartment (ship) , appendage , imaginal disc , biology , engrailed , hedgehog , cell lineage , microbiology and biotechnology , lineage (genetic) , drosophila (subgenus) , cellular compartment , cell fate determination , gene , cellular differentiation , evolutionary biology , gene expression , anatomy , cell , drosophila melanogaster , genetics , homeobox , signal transduction , transcription factor , biochemistry , oceanography , enzyme , geology
The appendages of Drosophila develop from the imaginal discs. During the extensive growth of these discs cell lineages are for the most part unfixed, suggesting a strong role for cell‐cell interactions in controlling the final pattern of differentiation. However, during early and middle stages of development, discs are subdivided by strict lineage restrictions into a small number of spatially distinct compartments. These compartments appear to be maintained by stably inheriting states of gene expression; the compartmentspecific expression of two such ‘selector’ ‐ like genes, engrailed and apterous , are critical for anterior‐posterior and dorso‐ventral compartmentalization, respectively. Recent work suggests that one purpose of compartmentalization is to establish regions of specialized cells near compartment boundaries via intercompartmental induction, using molecules like the hedgehog protein. Thus, compartments can act as organizing centers for patterning within compartments. Evidence for non‐compartmental patterning mechanisms will also be discussed.