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Nucleosomal anatomy – where are the histones?
Author(s) -
Pruss Dmitry,
Hayes Jeffrey J.,
Wolffe Alan P.
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170211
Subject(s) - nucleosome , chromatin , histone , biology , histone modifying enzymes , computational biology , evolutionary biology , genetics , microbiology and biotechnology , dna
The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, together with the implications of their association for the structure of the chromatin fibre.