Premium
E‐cadherin as a tumor (invasion) suppressor gene
Author(s) -
Birchmeier Walter
Publication year - 1995
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950170203
Subject(s) - cadherin , biology , suppressor , cancer research , gene , cell adhesion , cell adhesion molecule , cell , cancer , in vivo , tumor suppressor gene , carcinogenesis , microbiology and biotechnology , genetics
Diffuse‐type gastric carcinomas show diminished cell‐cell adhesion. A recent paper (1) reports that 50% of these carcinomas contain mutations in the E‐cadherin gene, resulting in the destruction of the calcium‐binding sites of E‐cadherin, and providing strong in vivo evidence that alterations in E‐cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.