Premium
Specificity in splicing
Author(s) -
Holliday Robin,
Murray Vincent
Publication year - 1994
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950161013
Subject(s) - rna splicing , intron , exon , gene , rna , biology , exonic splicing enhancer , post transcriptional modification , transcription (linguistics) , trans splicing , genetics , alternative splicing , computational biology , microbiology and biotechnology , linguistics , philosophy
Considerable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression, including alternative splicing, could be controlled by the transcription of specific splicer RNA genes. We re‐assess our model here, in the light of subsequent developments.