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Arrested development: Understanding v‐ abl
Author(s) -
Kerr Lawrence D.
Publication year - 1994
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950160702
Subject(s) - abl , lineage (genetic) , biology , tyrosine kinase , microbiology and biotechnology , oncogene , cellular differentiation , leukemia , gene , cancer research , signal transduction , cell cycle , genetics
The protein tyrosine kinase activity of the v‐ abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation. Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre‐B cell stage. Recent reports have characterized these cells expressing high v‐ abl kinase activity as deficient in detectable NF‐kB DNA binding activity and low level RAG gene expression. These observations suggest that v‐ abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway.