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Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome
Author(s) -
Cook Peter R.
Publication year - 1994
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950160611
Subject(s) - chromatin , polymerase , rna polymerase , rna polymerase i , rna polymerase ii , biology , genetics , microbiology and biotechnology , rna dependent rna polymerase , rna , dna , gene , gene expression , promoter
Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.