Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome | Zendy

Cook Peter R. | Zendy

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Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome

Author(s) -

Cook Peter R.

Publication year - 1994

Publication title -

bioessays

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.175

H-Index - 184

eISSN - 1521-1878

pISSN - 0265-9247

DOI - 10.1002/bies.950160611

Subject(s) - chromatin , polymerase , rna polymerase , rna polymerase i , rna polymerase ii , biology , genetics , microbiology and biotechnology , rna dependent rna polymerase , rna , dna , gene , gene expression , promoter

Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.

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