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The secretion pathway of IgA protease‐type proteins in gram‐negative bacteria
Author(s) -
Klauser Thomas,
Pohlner Johannes,
Meyer Thomas F.
Publication year - 1993
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950151205
Subject(s) - secretion , protease , microbiology and biotechnology , gram negative bacteria , biology , bacteria , escherichia coli , enzyme , biochemistry , genetics , gene
The pathogenic, Gram‐negative bacteria, Neisseria gon‐orrhoeae, Neisseria meningitidis and Haemophilus influenzae , secrete immunoglobulin A1 proteases into their extracellular surroundings. An extraordinary feature in the secretory pathway of these putative virulence factors is a self‐directed outer membrane transport step allowing the proteins to be secreted autonomously, even from foreign Gram‐negative host cells like Escherichia coli . Here we summarize recent achievements in the understanding of IgA protease outer membrane translocation.