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What's new: Conditional cell ablation in Drosophila
Author(s) -
Sentry J. W.,
Yang M. M.,
Kaiser K.
Publication year - 1993
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950150710
Subject(s) - enhancer , drosophila (subgenus) , biology , microbiology and biotechnology , cell , computational biology , enhancer trap , ablation , trap (plumbing) , genetics , gene expression , gene , physics , medicine , meteorology
Targeting of cell ablation agents under the control of tissue‐specific promoters promises to be an important tool for studies of development and function in higher organisms. Temperature‐sensitive cell ablation agents, recently developed for Drosophila , extend control to temporal as well as spatial aspects of toxin expression. Here we discuss achievements to date, together with a novel form of enhancer trap technology with the potential for driving toxin expression in a large range of cell types.