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The biology of hepatocyte growth factor/scatter factor
Author(s) -
Furlong Robert A.
Publication year - 1992
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950140908
Subject(s) - hepatocyte growth factor , morphogen , microbiology and biotechnology , growth factor , biology , motility , hepatocyte , cell , hepatocyte growth factor receptor , cell culture , cell growth , growth factor receptor , receptor , cancer research , signal transduction , genetics , c met , in vitro , gene
Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The membrane receptor for hepatocyte growth factor/scatter factor has been identified as the c‐ met proto‐oncogene product.