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Membrane protein insertion into the endoplasmic reticulum ‐ another channel tunnel?
Author(s) -
High Stephen
Publication year - 1992
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950140807
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , stim1 , biogenesis , membrane protein , membrane , membrane contact site , lipid bilayer , chemistry , biology , biophysics , biochemistry , integral membrane protein , gene
The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.