Premium
Poly(ADP‐ribose) polymerase: Molecular biological aspects
Author(s) -
De Murcia Gilbert,
MénissierDe Murcia Josiane,
Schreiber Valérie
Publication year - 1991
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950130905
Subject(s) - polymerase , poly adp ribose polymerase , cloning (programming) , biology , molecular cloning , gene , transformation (genetics) , function (biology) , enzyme , dna polymerase , microbiology and biotechnology , genetics , biochemistry , computational biology , gene expression , computer science , programming language
A number of roles have been ascribed to poly(ADP‐ribose) polymerase* including involvement in DNA repair, cell proliferation, differentiation and transformation. Cloning of the gene has allowed the development of molecular biological approaches to elucidate the structure and the function(s) of this highly conserved enzyme. This article will review the recent results obtained in this field.