Premium
The molecular basis for tropomyosin isoform diversity
Author(s) -
LeesMiller James P.,
Helfman David M.
Publication year - 1991
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950130902
Subject(s) - tropomyosin , multicellular organism , gene isoform , diversity (politics) , biology , function (biology) , actin , evolutionary biology , genetic diversity , computational biology , genetics , microbiology and biotechnology , cell , gene , population , demography , sociology , anthropology
The tropomyosins are a family of actin filament binding proteins. In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function.