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Parallels between development of embryonic and matrix‐induced endochondral bone
Author(s) -
Carrington Jill L.,
Reddi A. H.
Publication year - 1991
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950130807
Subject(s) - endochondral ossification , cartilage , microbiology and biotechnology , demineralized bone matrix , mesenchyme , bone healing , embryonic stem cell , matrix (chemical analysis) , bone marrow , anatomy , bone morphogenetic protein , biology , chemistry , embryo , immunology , materials science , genetics , dbm , amplifier , cmos , chromatography , gene , optoelectronics
Endochondral bone formation can take place in the embryo, during fracture healing, or in postnatal animals after induction by implanted demineralized bone matrix. This matrix‐induced bone formation recapitulates the embryonic sequence of bone formation morphologically and biochemically. The steps in bone formation in both systems include differentiation of cartilage from mesenchyme, cartilage maturation, invasion of the cartilage by blood vessels and marrow precursors, and formation of bone and bone marrow. Recently, bone inductive molecules from demineralized bone matrix have been purified, sequenced and produced as recombinant proteins. While there are similarities between bone development in the embryo and that after induction by these purified molecules, the molecules responsible for bone induction in the embryo have not yet been defined. Because of similarities between the two methods of bone formation, studies of Bone induction by demineralized bone matrix may help to elucidate mechanisms of embryonic bone induction.