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Yeast as a model system for understanding the control of DNA replication in eukaryotes
Author(s) -
Bartlett Rachel,
Nurse Paul
Publication year - 1990
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950121002
Subject(s) - eukaryotic dna replication , control of chromosome duplication , dna replication , origin recognition complex , dna re replication , pre replication complex , schizosaccharomyces pombe , biology , replication factor c , saccharomyces cerevisiae , origin of replication , genetics , cyclin dependent kinase 1 , microbiology and biotechnology , licensing factor , dna , gene , cell cycle
In the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe , the initiation of DNA replication is controlled at a point called START. At this point, the cellular environment is assessed; only if conditions are appropriate do cells traverse START, thus becoming committed to initiate DNA replication and complete the remainder of the cell cycle. The cdc 2 + / CDC 28 + gene, encoding the protein kinase p34, is a key element in this complex control. The identification of structural and functional homologues of p34 suggests that it has a role in the control of DNA replication in all eukaryotes. The WHI1 + , CLN1 + and CLN2 + gene products, identified in S. cerevisiae , are positive regulators that function at START and may interact with p34. Determining how passing the START control point leads to the initiation of DNA replication is a major outstanding challenge in cell cycle studies.
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