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S100 protein and down syndrome
Author(s) -
Marks Alexander,
Allore Robert
Publication year - 1990
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950120806
Subject(s) - s100 protein , biology , gene duplication , locus (genetics) , gene , calcium binding protein , central nervous system , down syndrome , gene dosage , genetics , microbiology and biotechnology , neuroscience , gene expression , calcium , medicine , immunology , immunohistochemistry
S100 protein is a low molecular weight calcium‐binding protein widely distributed in the central nervous system of vertebrates. Recent evidence suggests that S100 protein may play a role in the regulation of glial proliferation and neuronal differentiation. The gene for S100 protein has been mapped to the 21q22 region, a chromosomal locus whose duplication has been implicated in the generation of Down Syndrome (DS). This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS.