Premium
Growth‐related protein kinases
Author(s) -
Ralph Ray K.,
DarkinRattray Sandra,
Schofield Phillip
Publication year - 1990
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950120305
Subject(s) - casein kinase 1 , mitogen activated protein kinase kinase , map2k7 , c raf , ask1 , microbiology and biotechnology , kinase , biology , receptor tyrosine kinase , protein kinase a , map kinase kinase kinase , biochemistry , cyclin dependent kinase 2 , chemistry
Abstract A protein kinase cascade is involved in the action of some mitogens. The cascade begins with receptor tyrosine kinase activation by growth factors. The resulting signal is transmitted into cells via phospholipid metabolism which produces a variety of second messengers and by intracellular protein kinase activation. The signal is then propagated and disseminated via a network of other proteln kinases and protein phosphatases. Recent research suggests that ribosomal protein S6 kinase and casein kinase II are two important elements in the kinase cascade that leads to the initiation of growth. The nature and some properties of these hitherto lesser known enzymes is considered.