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Trichothiodystrophy and the relationship between DNA repair and cancer
Author(s) -
Lehmann A. R.
Publication year - 1989
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950110603
Subject(s) - dna repair , dna damage , biology , cancer , genetics , dna , nucleotide excision repair , cancer research
The identification of cellular deficiences in the ability to repair damage in DNA in individuals with several cancer‐prone genetic disorders, has led to the idea that defective DNA repair results in cancer. In patients with trichothiodystrophy, however, a recently discovered defect in the repair of ultraviolet damage in DNA is not associated with cancer‐proneness. Thus our previous ideas about the connections between DNA repair capacity and cancer susceptibility need to be reevaluated.