Premium
Generation of multiple N‐CAM polypeptides from a single gene
Author(s) -
Walsh Frank S.,
Dickson George
Publication year - 1989
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950110402
Subject(s) - gene isoform , gene , regulator , biology , transfection , microbiology and biotechnology , cell adhesion molecule , neural cell adhesion molecule , cell adhesion , skeletal muscle , computational biology , amino acid , cell , genetics , anatomy
The neural cell adhesion molecule (N‐CAM) is believed to be a key regulator of adhesive events in the nervous system and skeletal muscle. The recent isolation of N‐CAM cDNAs from different tissues has identified a high degree of diversity in primary amino acid sequence between different isoforms. In this article, we review these recent studies and discuss methods for unravelling the functional consequences of the generation of multiple N‐CAM polypeptides using gene transfection approaches.