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Structural characteristics of two highly selective opioid peptides
Author(s) -
Knapp Richard J.,
Yamamura Henry I.,
Kazmierski Wieslaw,
Hruby Victor J.
Publication year - 1989
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950100206
Subject(s) - opioid peptide , chemistry , opioid , computational biology , biology , biochemistry , receptor
The demonstration of opioid receptors by radioligand binding and the discovery of their endogenous peptide ligands has provided a new class of compounds that can be used for the development of novel opioids. The number of potential receptor targets for such opioids has been expanded by the identification of multiple opioid receptor types The development of highly selective opioid peptides using the principles of conformational restriction permits the analysis of the structure‐activity requirements of each receptor type, and is facilitating the elucidation of the functional properties of the different opioid receptors.