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The structural and functional interrelationships of muscarinic acetylcholine receptor subtypes
Author(s) -
Ramachandran J.,
Peralta E. G.,
Ashkenazi A.,
Winslow J. W.,
Capon D. J.
Publication year - 1989
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950100205
Subject(s) - muscarinic acetylcholine receptor , acetylcholine , muscarinic acetylcholine receptor m3 , muscarinic acetylcholine receptor m5 , muscarinic acetylcholine receptor m2 , biology , acetylcholine receptor , muscarinic acetylcholine receptor m4 , receptor , muscarinic acetylcholine receptor m1 , neurotransmitter receptor , gene , neurotransmitter , neuroscience , microbiology and biotechnology , genetics , pharmacology
Molecular cloning of the genes encoding the muscarinic acetylcholine receptors has shwon that receptor subtypes classified on the basis of pharmacological properties are related polypeptides encoded by distinct genes. These studies have laso revealed the existence of novel muscarinic receptor subtypes. Functional analysis of each of the subtypes expressed in mammalian cells indicates that the different subtypes activate distinct biochemical pathways, a finding that explains the tissue‐specific physiological response elicited by the neurotransmitter, acetylcholine.