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Selectivity in solute transport: Binding sites and channel structure in maltoporin and other bacterial sugar transport proteins
Author(s) -
Ferenci Thomas
Publication year - 1989
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950100102
Subject(s) - biophysics , chemistry , membrane transport , selectivity , channel (broadcasting) , microbiology and biotechnology , biology , biochemistry , membrane , computer science , catalysis , computer network
A stereospecific binding site is not the only determinant governing the selectivity of transport proteins. An understanding of transport across cellular membranes requires a description of the different compartments within a transmembrane channel; evidence for the existence of these compartments comes from the selectivity properties of genetically modified maltoporin. Such compartments may also be of significance in determining the specificity of other transport proteins.