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Genetic polymorphism and cancer susceptibility: Evidence concerning acetyltransferases and cancer of the urinary bladder
Author(s) -
Hein David W.
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950090605
Subject(s) - acetyltransferases , acetyltransferase , bladder cancer , arylamine n acetyltransferase , genotype , biology , allele , genetics , n acetyltransferase , locus (genetics) , mendelian inheritance , gene , acetylation , urinary bladder , genetic predisposition , cancer research , cancer , medicine
Acetyltransferase enzymes expressed in hepatic and extrahepatic tissues are products of an acetyltransferase gene locus. Acetylation capacity is regulated by simple autosomal Mendelian inheritance of two codominant alleles at this locus. Human slow acetylators are predisposed to bladder cancer from arylamine chemicals. The role of the bladder in arylamine metabolism and of bladder acetyltransferases in the etiology of bladder cancer is not fully understood, but the acetylator genotype‐dependent expression of arylamine N‐acetyltransferase and N‐hydroxyarylamine O‐acetyltransferase in bladder cytosol may contribute towards the genetic predisposition of human slow acetylators to arylamine‐induced bladder cancer.