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Novel cell surface receptors during mammalian fertilization and development
Author(s) -
Hathaway Helen J.,
Shur Barry D.
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950090504
Subject(s) - microbiology and biotechnology , extracellular matrix , extracellular , cell surface receptor , cell , intracellular , cell adhesion , biology , receptor , cell–cell interaction , cell membrane , cell adhesion molecule , glycoconjugate , cell type , biochemistry
Embryogenesis requires the precise movement and reorganization of many cell and tissue types. Presumably, cell surface receptors allow cells to interact selectively with adjacent cells and with the extracellular environment, as well as initiate differentiative events by transducing appropriate signals across the plasma membrane. One cell surface component that serves as a receptor during a variety of cellular interactions is β1,4‐galactosyltransferase. Cell surface galactosyltransferase participates in diverse cellular interactions by binding its specific glycoconjugate substrate on adjacent cell surfaces or in the extracellular matrix. Biochemical, immunological, and molecular probes are being used to better define cell surface galactosyl‐transferase functional in cellular interactions during fertilization, intercellular adhesion, cell migration, and growth control.