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On the architecture of regulatory systems: Evolutionary insights and implications
Author(s) -
Dickinson W. J.
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950080608
Subject(s) - constraint (computer aided design) , biology , evolutionary biology , interspecific competition , computational biology , diversity (politics) , systems biology , value (mathematics) , gene regulatory network , gene , genetics , computer science , gene expression , ecology , mathematics , political science , machine learning , geometry , law
Abstract Interspecific comparisons reveal remarkable diversity in patterns of gene expression, even among closely related species. Combinatorial regulatory mechanisms could facilitate the evolution of this diversity. However, the high degree of interdependence characteristic of combinatorial networks would represent a major constraint on evolution and might generate many features that have no direct adaptive value.