Premium
A family of closely related ATP‐binding subunits from prokaryotic and eukaryotic cells
Author(s) -
Higgins Christopher F.,
Gallagher Maurice P.,
Mimmack Michael L.,
Pearce Stephen R.
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950080406
Subject(s) - atp hydrolysis , biology , biochemistry , function (biology) , dna , microbiology and biotechnology , genetics , atpase , enzyme
A large number of cellular proteins bind ATP, frequently utilizing the free energy of ATP hydrolysis to drive specific biological reactions. Recently, a family of closely related ATP‐binding proteins has been identified, the members of which share considerable sequence identity. These proteins, from both prokaryotic and eukaryotic sources, presumably had a common evolutionary origin and include the product of the white locus of Drosophila , the P‐glycoprotein which confers multidrug resistance on mammalian tumours, and prokaryotic proteins associated with such diverse processes as membrane transport, cell division, nodulation and DNA repair. A comparison of these various proteins provides valuable insights into the function and evolution of the multicomponent systems with which they are associated.