Premium
The pivotal role of ferritin in cellular iron homeostasis
Author(s) -
Mattia Elena,
van Renswoude Jos
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950080405
Subject(s) - ferritin , iron homeostasis , intracellular , transferrin , transferrin receptor , homeostasis , microbiology and biotechnology , chemistry , cell , biochemistry , biology , metabolism
Iron delivered by transferrin to the interior of the cell is in part utilized in biosynthetic processes and in part incorporated into ferritin, the major iron storage protein. The intracellular ferritin concentration is directly correlated to and determined by the extent of iron supply to the cell. Intracellular partitioning of iron to ferritin is suggested as forming the basis of cellular iron homeostasis.