Premium
On transition metal ions and protein interactions in chromatin
Author(s) -
Saavedra Raul A.
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950080108
Subject(s) - chromatin , histone , dna , chemistry , histone h3 , metal ions in aqueous solution , microbiology and biotechnology , ion , genetics , biology , biochemistry , organic chemistry
Metal ions may play an essential role in chromatin organization and, thus, be main actors in the gene expression drama. A model is proposed here for the interaction of DNA‐binding transcriptional regulatory proteins with histone H3 via coordinated metal ions and discussed in relation to the conversion of nucleosomal ‘closed’ to ‘open’ states.