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Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque
Author(s) -
Kellie Stuart
Publication year - 1988
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950080107
Subject(s) - ptk2 , tyrosine kinase , tyrosine , tyrosine phosphorylation , vinculin , microbiology and biotechnology , cell adhesion , focal adhesion , transformation (genetics) , integrin , receptor tyrosine kinase , sh2 domain , platelet derived growth factor receptor , biology , chemistry , phosphorylation , cell , biochemistry , signal transduction , protein kinase a , mitogen activated protein kinase kinase , receptor , growth factor , gene
The study of adhesion plaques in normal and transformed cells provides a series of phenotypic markers by which the process of transformation can be followed. Several proteins which are concentrated in adhesion plaques have now been identified; a few of these can act as targets for tyrosine kinase. In an attempt to characterize the relationship between tyrosine phosphorylation and cell transformation, the reactions of three such proteins – vinculin, talin and integrin – with a range of tyrosine kinase oncogene products have been studied in detail.