Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque | Zendy

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Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque

Author(s) -

Kellie Stuart

Publication year - 1988

Publication title -

bioessays

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.175

H-Index - 184

eISSN - 1521-1878

pISSN - 0265-9247

DOI - 10.1002/bies.950080107

Subject(s) - ptk2 , tyrosine kinase , tyrosine , tyrosine phosphorylation , vinculin , microbiology and biotechnology , cell adhesion , focal adhesion , transformation (genetics) , integrin , receptor tyrosine kinase , sh2 domain , platelet derived growth factor receptor , biology , chemistry , phosphorylation , cell , biochemistry , signal transduction , protein kinase a , mitogen activated protein kinase kinase , receptor , growth factor , gene

The study of adhesion plaques in normal and transformed cells provides a series of phenotypic markers by which the process of transformation can be followed. Several proteins which are concentrated in adhesion plaques have now been identified; a few of these can act as targets for tyrosine kinase. In an attempt to characterize the relationship between tyrosine phosphorylation and cell transformation, the reactions of three such proteins – vinculin, talin and integrin – with a range of tyrosine kinase oncogene products have been studied in detail.

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