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Ribosomal protein autoantibodies in systemic lupus erythematosus
Author(s) -
Elkon Keith,
Bonfa Eloisa,
Skelly Susan,
Weissbach Herbert,
Brot Nathan
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950070607
Subject(s) - autoantibody , immunology , epitope , ribosomal protein , ribosomal rna , psychosis , systemic lupus erythematosus , medicine , antibody , lupus erythematosus , systemic disease , biology , disease , immunopathology , ribosome , genetics , psychiatry , rna , gene
Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10–20% of patients with systemic lupus erythematosus (SLE). These three proteins share a common epitope contained within the carboxy terminal 22 amino acids of each protein. Because central nervous system disturbances, with major behavioural disorders, occur in a significant fraction of SLE patients, the antiribosomal autoantibodies were measured in this subset of SLE individuals to determine whether or not there was an association. This antibody is present in 90% of SLE patients who were diagnosed as having psychosis, secondary to the disease.