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Calpactins: Calcium‐regulated membrane‐skeletal proteins
Author(s) -
Glenney John R.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950070408
Subject(s) - spectrin , cytoskeleton , actin , calcium , immunoglobulin light chain , microbiology and biotechnology , membrane protein , chemistry , biophysics , calcium binding protein , membrane , biology , biochemistry , antibody , cell , genetics , organic chemistry
The calpactins are a novel group of proteins associated with the membrane skeleton. The two main forms, calpactin I and II, have been shown to bind to the cytoskeletal proteins actin and spectrin, as well as to anionic phospholipids, which may imply some sort of bridging role. By raising monoclonal antibodies to the heavy and light chains of calpactin I, and to calpactin II, the protein subunits were shown to be coordinately expressed, and the existence of separate calpactin pools hypothesized. Calcium‐binding studies suggest that the calpactins may translate Ca 2+ signals into cellular responses at the membrane. Structural studies have revealed two distinct domains and are beginning to throw light on heavy‐‐light chain interaction and cytoskeletal attachment.