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The control of transcription in Saccharomyces cerevisiae
Author(s) -
Stanway Clive,
Kingsman Alan J.,
Kingsman Susan M.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950070204
Subject(s) - saccharomyces cerevisiae , transcription (linguistics) , chromatin , promoter , eukaryote , response element , microbiology and biotechnology , tata box , dna , biology , rna , messenger rna , eukaryotic transcription , transcription factor , gene , genetics , gene expression , genome , linguistics , philosophy
The control of mRNA synthesis in the unicellular eukaryote Saccharomyces cerevisiae involves a number of promoter elements, including an upstream activation site (UAS), an RNA initiation element (RIE) and, for some genes, a form of negative element. The UAS is involved in the activation and regulation of transcription, whilst the RIE, which comprises a transcription initiation site (or I site), and often a TATA box, is responsible for the accurate positioning of the 5′ end of the mRNA. The mechanism whereby these promoter elements interact involves specific protein‐DNA binding events and possibly alterations in chromatin structure.