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Mitogen‐specific nonresponsive mutants and the initiation of cellular proliferation
Author(s) -
Herschman Harvey R.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950060606
Subject(s) - mitogen activated protein kinase , cell division , microbiology and biotechnology , cell growth , biology , mutant , cell culture , cell , genetics , signal transduction , gene
A large number of molecular, physiological, and biochemical events accompany the mitogen‐induced transition from a quiescent, nonproliferating state to a cycling state. However, it is difficult to distinguish causal steps in the commitment to cell division from correlative events. To approach this problem we have isolated mitogen‐specific nonproliferative variants of 3T3 cells, namely cell lines that are unable to mount a mitogenic response to specific mitogens.