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Regulation of messenger RNA stability in eukaryotic cells
Author(s) -
Shapiro David J.,
Blume John E.,
Nielsen David A.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950060507
Subject(s) - messenger rna , microbiology and biotechnology , cytoplasm , rna , biology , mature messenger rna , computational biology , mechanism (biology) , chemistry , genetics , gene , physics , non coding rna , quantum mechanics
Regulation of the cytoplasmic stability of mRNAs has recetly been identified as a major control mechanism which governs mRNA levels in a variety of eukaryotic systems. In this review we discuss what is known about several experimental systems that exhibit regulated mRNA stability, describe the mechanisms that cells may use to achieve control of mRNA degradation, and suggest areas of future investigation likely to provide new insights into this process.