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Dengue haemorrhagic fever: Virus or host response?
Author(s) -
Pang Tikki
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950060311
Subject(s) - dengue fever , dengue virus , virology , virus , biology , virulence , host (biology) , immune system , pathogenesis , disease , host factors , immunology , host response , antibody dependent enhancement , mechanism (biology) , dengue vaccine , gene , medicine , genetics , pathology , philosophy , epistemology
Abstract The pathogenesis of dengue haemorrhagic fever has been the subject of intense research and considerable controversy. One hypothesis proposes that the immune response in a sensitized host is the primary mechanism. In contrast, others have suggested that the disease is caused by a more virulent, variant strain of dengue virus. Recent advances in molecular biology and hybridoma technology are providing valuable clues toward a solution and illustrating the fact that the course of a human viral disease is often a net result of unseparated interactions between host and virus.