Premium
DNA interactions with the nuclear matrix and spatial organization of replication and transcription
Author(s) -
Razin S. V.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950060106
Subject(s) - nuclear matrix , biology , interphase , dna replication , scaffold/matrix attachment region , dna , transcription (linguistics) , genetics , microbiology and biotechnology , control of chromosome duplication , matrix (chemical analysis) , origin recognition complex , gene , cell nucleus , eukaryotic dna replication , transcription factor , chemistry , chromatin , linguistics , philosophy , chromatography , chromatin remodeling
Analysis of the DNA sequence associated with the nuclear matrix has made it possible to identify several types of DNA matrix association. Permanent attachment sites are detected in both transcriptionally active and inactive nuclei. Furthermore, replication origins have been shown to be permanently attached to the nuclear matrix. In transcriptionally active nuclei, expressed genes are also associated with the nuclear matrix. Finally, a special group of attachment sites is described; these sites are believed to maintain the fixed positions of individual chromosomes in interphase nuclei.