Premium
Retinoblastoma – genetic insights into neoplasia
Author(s) -
Nyhan William L.
Publication year - 1987
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950060103
Subject(s) - retinoblastoma , allele , malignancy , genetics , biology , gene , suppressor , tumor suppressor gene , mutant , cancer research , carcinogenesis
Retinoblastoma is a highly malignant ocular tumor that has been known to be hereditary in some instances. New information from cytogenetic and molecular studies indicates that there is a retinoblastoma gene and that the mutant alleles are recessive. The wild‐type gene appears to be a suppressor of this neoplasia, and, when both alleles are lost, malignancy develops.