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Site‐specific mutagenesis of large DNA viral genomes
Author(s) -
Jenkins Frank J.,
Roizman Bernard
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050603
Subject(s) - genome , mutagenesis , biology , dna , computational biology , selectable marker , genetics , mutation , gene , plasmid
Site‐specific or target‐specific mutagenesis of viral DNA genomes, using a selectable marker system is a powerful tool for the analysis of the function of specific regions of large DNA genomes. Through these techniques the construction of vectors capable of delivering vaccines for the prevention of infectious disease in humans and animals is possible.