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The Drosophila position‐specific antigens. Clues to their morphogenetic role
Author(s) -
Leptin Maria,
Wilcox Michael
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050504
Subject(s) - biology , microbiology and biotechnology , glycoprotein , compartment (ship) , antigen , fibronectin , morphogenesis , vertebrate , function (biology) , receptor , drosophila (subgenus) , genetics , gene , extracellular matrix , oceanography , geology
The Drosophila position‐specific antigens are a family of cell‐surface glycoprotein complexes showing spatially restricted patterns of expression. Changes in these distributions correlate with morphogenetic events like compartment‐alization and the formation of grooves and folds during tissue organization. The complexes each contain a common component associated with different variable components. Different tissues, organs and regions of the body express complexes containing different subsets of variable components. The structure of the complexes resembles that of the family of vertebrate receptors for fibronectin, molecules which function in morphogenetic processes involving cell migration and attachment. It is possible that the position‐specific antigens have a similar role in fly development.