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Molecular biology of T‐cell‐derived lymphokines: A model system for proliferation and differentiation of hemopoietic cells
Author(s) -
Arai K.,
Yokota T.,
Miyajima A.,
Arai N.,
Lee F.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050407
Subject(s) - lymphokine , haematopoiesis , biology , microbiology and biotechnology , recombinant dna , gene , immunology , stem cell , genetics , immune system
Many lymphokine genes have now been cloned from activated T cells and their products have been expressed in mammalian cells. Use of these recombinant lymphokines has provided the opportunity to evaluate both the spectrum of their biological activities and the mechanisms of their action in promoting proliferation and differentiation of hemopoietic and lymphoid cells. Characterization of the structure of lymphokine genes will provide information about their regulated expression in T‐cell activation.