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Lymphocyte homing receptors and the immune response in vivo
Author(s) -
Weissman Irving L.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050305
Subject(s) - homing (biology) , immune system , lymphocyte homing receptor , receptor , biology , immunology , lymphatic system , lymphocyte , in vivo , microbiology and biotechnology , cell , genetics , cell adhesion , ecology
An important aspect of the developmental maturation of lymphocytes is their capacity to locate and enter lymphoid organs with great rapidity and specificity and to follow certain routes within these organs for the attainment of particular immunological capabilities. It is now known that this “homing response” to lymphoid organs involves specific glycoprotein receptors on the lymphocyte cell surface. The biochemistry of these receptors and their significance in normal and pathological immune responses are discussed.