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Multiple levels of gene regulations in the control of amino acid biosynthesis in Saccharomyces cerevisiae
Author(s) -
Hinnebusch Alan G.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050204
Subject(s) - saccharomyces cerevisiae , activator (genetics) , gene , yeast , amino acid , gene expression , regulation of gene expression , biology , biosynthesis , regulator gene , mechanism (biology) , biochemistry , transcriptional regulation , genetics , philosophy , epistemology
In the yeast Saccharomyces cerevisiae, the regulation of expression of many of the enzymes for amino acid biosynthesis involves an interlinked general control system. Molecular and genetic analyses of this system reveal an underlying set of hierarchical transcriptional controls and a novel translational regulatory mechanism for governing expression of a key activator gene.