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Retroviral elements and suppressor genes in Drosophila
Author(s) -
Parkhurst Susan M.,
Corces Victor G.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050203
Subject(s) - transposable element , biology , genetics , gene , enhancer , phenotype , allele , suppressor , drosophila melanogaster , drosophila (subgenus) , mutation , dna transposable elements , drosophilidae , mutant , gene expression
The phenotype of some spontaneous mutations in Drosophila can be modified by mutations at unlinked loci. The affected alleles are caused by the insertion of retroviral transposable elements. The idiosyncratic functional and structural properties of these elements play a key role in determining the expression characteristics of the genes into which they are inserted. These phenotypes are reversed or intensified by the allelic state of suppressor and enhancer loci through changes in the transcriptional properties of the transposable elements.