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The molecular biology of differentiation and proliferation using human myelogenous leukemia cells
Author(s) -
Miller Carl,
Koeffler H. Phillip
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950050106
Subject(s) - biology , cellular differentiation , myeloid , neoplastic transformation , transformation (genetics) , chromatin , myeloid leukemia , microbiology and biotechnology , nuclear matrix , oncogene , leukemia , proto oncogenes , cancer research , point mutation , mutation , cell , genetics , dna , cell cycle , gene , carcinogenesis
Abstract Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D 3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation.