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What the papers say: The influence of immunoglobulin genes in lymphoid oncogenesis
Author(s) -
Adams Jerry M.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950040608
Subject(s) - carcinogenesis , biology , locus (genetics) , germline , gene , chromosomal translocation , genetics , immunoglobulin gene , antibody , oncogene , cell cycle
Illuminating insights into lymphoid oncogenesis came with the finding that the chromosome translocations characteristic of many tumors of immunoglobulin‐producing cells represent conjunction of an immunoglobulin gene locus with the myc oncogene. The potency of this combination has been underlined by recent studies in which DNA regions mimicking certain chromosome junctions of lymphomas were shown to be highly tumorigenic when inserted into the mouse germline. Nevertheless, the mechanism by which an immunoglobulin locus activates the oncogene remains largely an enigma, particularly in those cases where the two loci remain at some distance.